Dr. Ron’s Research Review – April 21, 2010

 

In this week’s research review we have three articles on obesity:

An article on endocrine-disrupting chemicals that may cause perturbations in endogenous hormonal regulation and alter other mechanisms involved in weight homeostasis

A review article on 11ß-HSD, an important regulator at the interface of obesity and inflammation

Progesterone: a "weight watcher's pill" for reproductively aging women

 

Dr. Ron

 

Abstracts

Putative environmental-endocrine disruptors and obesity: a review

(Elobeid and Allison 2008) Download

Recent evidence suggests that endocrine-disrupting chemicals, for example halogenated aromatic hydrocarbons, may cause perturbations in endogenous hormonal regulation and alter other mechanisms involved in weight homeostasis, which may lead to weight gain by increased volume of adipose tissue. Synthetic chemicals derived from industrial processes are suspected to play a contributory role. Yet of the approximately 70,000 documented synthetic chemicals, few have been examined to determine their effects on the endocrine system.

 

11beta-Hydroxysteroid dehydrogenase type 1 is an important regulator at the interface of obesity and inflammation

            (Staab and Maser 2010) Download

Systemic glucocorticoid excess, as exemplified by the Cushing syndrome, leads to obesity and all further symptoms of the metabolic syndrome. The current obesity epidemic, however, is not characterized by increased plasma cortisol concentrations, but instead comes along with chronic low-grade inflammation in adipose tissue and concomitant increased levels of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1, gene HSD11B1), a parameter known to cause obesity in a mouse model. 11beta-HSD1 represents an intracellular amplifier of active glucocorticoid, thus enhances the associated effects on the inflammatory response as well as on nutrient and energy metabolism, and may therefore cause and exacerbate obesity by local increase of glucocorticoid concentrations. Obtained by extensive literature and database searching, the present review includes comprehensive lists of primary glucocorticoid-sensitive genes and gene products as well as of the thus far known regulators of HSD11B1 expression with implication in inflammation and metabolic disease. Collectively, the data clearly show that, in addition to amplifying active glucocorticoid and thus profoundly modulating inflammation and nutrient metabolism, 11beta-HSD1 is subject to tight control of multiple additional immunomodulatory and metabolic regulators. Hence, 11beta-HSD1 acts at the interface of inflammation and obesity and represents an efficient integrator and effector of local inflammatory and metabolic state.

 

Progesterone: a "weight watcher's pill" for reproductively aging women

            (Pal 2006) Download

 

 

References

Elobeid, M. A. and D. B. Allison (2008). "Putative environmental-endocrine disruptors and obesity: a review." Curr Opin Endocrinol Diabetes Obes 15(5): 403-8.

Pal, L. (2006). "Progesterone: a "weight watcher's pill" for reproductively aging women." Menopause 13(2): 166-7.

Staab, C. A. and E. Maser (2010). "11beta-Hydroxysteroid dehydrogenase type 1 is an important regulator at the interface of obesity and inflammation." J Steroid Biochem Mol Biol 119(1-2): 56-72.