Dr. Ron’s Research Review - January 6, 2010

 

This week’s research review focuses on new research on11ß-HSD, a historical perspective on cortisone, and the therapeutic use of Fucus vesiculosus (bladderwrack).

 

Perhaps the most interesting article is on the contraindication of licorice with 11ß-HSD type 2 mutations.

 

 

Glucocorticoids and cardiovascular disease

            (Walker 2007) Download

 

Herbal Medicine Containing Licorice May Be Contraindicated for a Patient With an HSD11B2 Mutation

            (Harahap, Sasaki et al. 2009) Download

 

Inhibition of 11beta-hydroxysteroid dehydrogenase type II selectively blocks the tumor COX-2 pathway and suppresses colon carcinogenesis in mice and humans

            (Zhang, Xu et al. 2009) Download

 

Diamonds are forever: the cortisone legacy

            (Hillier 2007) Download

 

The effect of Fucus vesiculosus, an edible brown seaweed, upon menstrual cycle length and hormonal status in three pre-menopausal women: a case report

(Skibola 2004) Download

These pilot data suggest that dietary bladderwrack may prolong the length of the menstrual cycle and exert anti-estrogenic effects in pre-menopausal women.

 

Brown kelp modulates endocrine hormones in female sprague-dawley rats and in human luteinized granulosa cells

            (Skibola, Curry et al. 2005) Download

 


References

 

Harahap, I. S., N. Sasaki, et al. (2009). "Herbal Medicine Containing Licorice May Be Contraindicated for a Patient With an HSD11B2 Mutation." Evid Based Complement Alternat Med.

Hillier, S. G. (2007). "Diamonds are forever: the cortisone legacy." J Endocrinol 195(1): 1-6.

Skibola, C. F. (2004). "The effect of Fucus vesiculosus, an edible brown seaweed, upon menstrual cycle length and hormonal status in three pre-menopausal women: a case report." BMC Complement Altern Med 4: 10.

Skibola, C. F., J. D. Curry, et al. (2005). "Brown kelp modulates endocrine hormones in female sprague-dawley rats and in human luteinized granulosa cells." J Nutr 135(2): 296-300.

Walker, B. R. (2007). "Glucocorticoids and cardiovascular disease." Eur J Endocrinol 157(5): 545-59.

Zhang, M. Z., J. Xu, et al. (2009). "Inhibition of 11beta-hydroxysteroid dehydrogenase type II selectively blocks the tumor COX-2 pathway and suppresses colon carcinogenesis in mice and humans." J Clin Invest 119(4): 876-85.