Dr. Ron’s Research Review – May 5, 2010

 

This week’s research review has an article on iodine:

“Iodine deficiency may give rise to clinical symptoms of hypothyroidism without abnormality of thyroid hormone values”

 

The second article is on Crocus (saffron) for male erectile dysfunction.

            Tri-Quench contains Crocus and SSKI.

 

The third article is on testosterone for erectile dysfunction.

 

 

Dr. Ron

 

Iodine deficiency, more than cretinism and goiter

(Verheesen and Schweitzer 2008) Download

Recent reports of the World Health Organization show iodine deficiency to be a worldwide occurring health problem. As iodine status is based on median urinary iodine excretion, even in countries regarded as iodine sufficient, a considerable part of the population may be iodine deficient. Iodine is a key element in the synthesis of thyroid hormones and as a consequence, severe iodine deficiency results in hypothyroidism, goiter, and cretinism with the well known biochemical alterations. However, it is also known that iodine deficiency may give rise to clinical symptoms of hypothyroidism without abnormality of thyroid hormone values. This led us to the hypothesis that iodine deficiency may give rise to subtle impairment of thyroid function leading to clinical syndromes resembling hypothyroidism or diseases that have been associated with the occurrence of hypothyroidism. We describe several clinical conditions possibly linked to iodine deficiency, a connection that has not been made thus far. In this paper we will focus on the relationship between iodine deficiency and obesity, attention deficit hyperactivity disorder (ADHD), psychiatric disorders, fibromyalgia, and malignancies.

 

Evaluation of Crocus sativus L. (saffron) on male erectile dysfunction: a pilot study

(Shamsa, Hosseinzadeh et al. 2009) Download           

In this study, the effect of Crocus sativus (saffron) was studied on male erectile dysfunction (ED). Twenty male patients with ED were followed for ten days in which each morning they took a tablet containing 200mg of saffron. Patients underwent the nocturnal penile tumescence (NPT) test and the international index of erectile function questionnaire (IIEF-15) at the start of the treatment and at the end of the ten days. After the ten days of taking saffron there was a statistically significant improvement in tip rigidity and tip tumescence as well as base rigidity and base tumescence. ILEF-15 total scores were significantly higher in patients after saffron treatment (before treatment 22.15+/-1.44; after treatment 39.20+/-1.90, p<0.001). Saffron showed a positive effect on sexual function with increased number and duration of erectile events seen in patients with ED even only after taking it for ten days.

 

Testosterone gel monotherapy improves sexual function of hypogonadal men mainly through restoring erection: evaluation by IIEF score

            (Chiang, Cho et al. 2009) Download

OBJECTIVES: To use the International Index of Erectile Function (IIEF) to evaluate the improvement of erectile function and other sexual functions after testosterone monotherapy. Testosterone replacement therapy alone was reported to be effective for the improvement in sexual function in hypogonadal males. However, it is still unclear that which kind of the sexual function is most beneficial and to what extent the sexual function could be improved. METHODS: A double-blind, randomized, placebo-controlled study was conducted with a treatment group (n = 20) and control group (n = 20). Using a critical review of the different sexual functional domain scores of the IIEF-15 and the scores of the IIEF-5, we evaluated the sexual function of men in hypogonadal status before and after 3 months of testosterone gel treatment. Effect size was used to compare the drug effects for each sexual functional domain, and the results were confirmed by multivariate analysis. RESULTS: A total of 30 men remained at the end of the study. After 3 months of testosterone gel therapy for the hypogonadal men, the most beneficial effect on sexual function was erectile function, with sexual desire and orgasmic satisfaction insignificantly affected. CONCLUSIONS: The results of our study have shown that transdermal testosterone gel treatment for hypogonadal patients can improve their sexual dysfunction mainly through restoring erectile function.

 

References

Chiang, H. S., S. L. Cho, et al. (2009). "Testosterone gel monotherapy improves sexual function of hypogonadal men mainly through restoring erection: evaluation by IIEF score." Urology 73(4): 762-6.

Shamsa, A., H. Hosseinzadeh, et al. (2009). "Evaluation of Crocus sativus L. (saffron) on male erectile dysfunction: a pilot study." Phytomedicine 16(8): 690-3.

Verheesen, R. H. and C. M. Schweitzer (2008). "Iodine deficiency, more than cretinism and goiter." Med Hypotheses 71(5): 645-8.