Dr. Ron’s Research Review – July 6, 2011

This week’s research review focuses on rubidium.

If rubidium is found in salami, then the occasional slice could be more beneficial for people suffering from depression than taking a lot of medication. (Canavese, Decostanzi et al. 2008)

Although antidepressant action of rubidium has not been supported by adequate number of controlled studies, its potential contribution to psychiatry warrants further investigations. (Malek-Ahmadi and Williams 1984)

Rubidium tends to increase the length of manic phases and possibly reduces the extremes of mood. Rubidium did not seem to produce any severe side effects in the dose administered (rubidium chloride 50g/l, 410 mmol/l), but it has a long biological half-life and caution is still required. (Paschalis, Jenner et al. 1978)

Dr. Ron


Articles

Rubidium, salami and depression. You cannot have everything in life

            (Canavese, Decostanzi et al. 2008) Download

BACKGROUND: Depression may induce malnutrition, but, as a paradoxical hypothesis, malnutrition may induce depression. This relationship, of course, depends on how we define malnutrition. CURRENT KNOWLEDGE: Rubidium is a trace element strongly linked with depression, and is deficient in uremia sufferers. However, in uremic patients, rubidium deficiency is more evident during predialysis, as it is at least partially corrected during dialysis and after transplantation. It seems that diet restrictions might be the main cause of rubidium deficiency, as it is mainly found in red meat. CONCLUSION: If rubidium is found in salami, then the occasional slice could be more beneficial for people suffering from depression than taking a lot of medication.

Rubidium in psychiatry: research implications

            (Malek-Ahmadi and Williams 1984) Download

A brief overview of the use of rubidium in affective disorders and schizophrenia is presented. Although antidepressant action of rubidium has not been supported by adequate number of controlled studies, its potential contribution to psychiatry warrants further investigations. Endogenous rubidium may be a useful research tool in the future psychopharmacological studies of affective disorders.

Rubidium: a potential modifier of affect and behaviour

            (Meltzer, Taylor et al. 1969) Download

Effects of rubidium chloride on the course of manic-depressive illness

            (Paschalis, Jenner et al. 1978) Download

Clinical studies of the effects of rubidium ions on the course of manic-depressive illness are reported. It seems that rubidium tends to increase the length of manic phases and possibly reduces the extremes of mood. Rubidium did not seem to produce any severe side effects in the dose administered, but it has a long biological half-life and caution is still required. Some details of the CSF, RBC, saliva and plasma and urine kinetics are also reported.


References

Canavese, C., E. Decostanzi, et al. (2008). "Rubidium, salami and depression. You cannot have everything in life." Blood Purif 26(4): 311-4.

Malek-Ahmadi, P. and J. A. Williams (1984). "Rubidium in psychiatry: research implications." Pharmacol Biochem Behav 21 Suppl 1: 49-50.

Meltzer, H. L., R. M. Taylor, et al. (1969). "Rubidium: a potential modifier of affect and behaviour." Nature 223(5203): 321-2.

Paschalis, C., F. A. Jenner, et al. (1978). "Effects of rubidium chloride on the course of manic-depressive illness." J R Soc Med 71(5): 343-52.