Dr. Ron’s Research Review – January 25, 2012

This week’s research review presents Ashwagandha and Vitamin D to increase testosterone levels.

Ashwgandha

A recent study found that Withania somnifera inhibited lipid peroxidation and protein carbonyl content and improved sperm count and motility. Treatment of infertile men recovered the seminal plasma levels of antioxidant enzymes and vitamins A, C, and E and corrected fructose. Moreover, treatment also significantly increased serum T and LH and reduced the levels of FSH and PRL. (Ahmad, Mahdi et al. 2010)

Vitamin D

A study included 200 non-diabetic subjects, of whom 165 participants (54 men) completed the trial. Participants received either 83 mug (3 332 IU) vitamin D daily for 1 year (n=31) or placebo (n=23). Initial 25(OH)D concentrations were in the deficiency range (<50 nmol/l) and testosterone values were at the lower end of the reference range (9.09-55.28 nmol/l for males aged 20-49 years) in both groups. Mean circulating 25(OH)D concentrations increased significantly by 53.5 nmol/l in the vitamin D group, but remained almost constant in the placebo group. Compared to baseline values, a significant increase in total testosterone levels (from 10.7+/-3.9 nmol/l to 13.4+/-4.7 nmol/l; p<0.001), bioactive testosterone (from 5.21+/-1.87 nmol/l to 6.25+/-2.01 nmol/l; p=0.001), and free testosterone levels (from 0.222+/-0.080 nmol/l to 0.267+/-0.087 nmol/l; p=0.001) were observed in the vitamin D supplemented group. By contrast, there was no significant change in any testosterone measure in the placebo group. Our results suggest that vitamin D supplementation might increase testosterone levels. (Pilz, Frisch et al. 2010)

The metabolism chart is in the hormone handbook

http://tahomaclinic.com/Private/Articles1eb/Hormones.html

http://tahomaclinic.com/Private/Articles1eb/Images/Testosterone.jpg

Dr. Ron


Articles

Withania somnifera improves semen quality by regulating reproductive hormone levels and oxidative stress in seminal plasma of infertile males

            (Ahmad, Mahdi et al. 2010) Download

OBJECTIVE: To investigate the impact of Withania somnifera roots on semen profile, oxidative biomarkers, and reproductive hormone levels of infertile men. DESIGN: Prospective study. SETTING: Departments of Biochemistry and Urology, Chhatrapati Shahuji Maharaj Medical University, Lucknow, India. PATIENT(S): Seventy-five normal healthy fertile men (control subjects) and 75 men undergoing infertility screening. INTERVENTION(S): High-performance liquid chromatography assay procedure for quantization of vitamin A and E in seminal plasma. Biochemical parameters in seminal plasma were estimated by standard spectrophotometric procedures. Estimation of T, LH, FSH, and PRL in blood serum by RIA methods. MAIN OUTCOME MEASURES(S): Before and after the treatment, seminal plasma biochemical parameters, antioxidant vitamins, and serum T, LH, FSH, and PRL levels were measured. RESULT(S): Withania somnifera inhibited lipid peroxidation and protein carbonyl content and improved sperm count and motility. Treatment of infertile men recovered the seminal plasma levels of antioxidant enzymes and vitamins A, C, and E and corrected fructose. Moreover, treatment also significantly increased serum T and LH and reduced the levels of FSH and PRL. CONCLUSION(S): The treatment with W. somnifera effectively reduced oxidative stress, as assessed by decreased levels of various oxidants and improved level of diverse antioxidants. Moreover, the levels of T, LH, FSH and PRL, good indicators of semen quality, were also reversed in infertile subjects after treatment with the herbal preparation.

Effect of vitamin D supplementation on testosterone levels in men

         (Pilz, Frisch et al. 2010) Download

The male reproductive tract has been identified as a target tissue for vitamin D, and previous data suggest an association of 25-hydroxyvitamin D [25(OH)D] with testosterone levels in men. We therefore aimed to evaluate whether vitamin D supplementation influences testosterone levels in men. Healthy overweight men undergoing a weight reduction program who participated in a randomized controlled trial were analyzed for testosterone levels. The entire study included 200 nondiabetic subjects, of whom 165 participants (54 men) completed the trial. Participants received either 83 mug (3 332 IU) vitamin D daily for 1 year (n=31) or placebo (n=23). Initial 25(OH)D concentrations were in the deficiency range (<50 nmol/l) and testosterone values were at the lower end of the reference range (9.09-55.28 nmol/l for males aged 20-49 years) in both groups. Mean circulating 25(OH)D concentrations increased significantly by 53.5 nmol/l in the vitamin D group, but remained almost constant in the placebo group. Compared to baseline values, a significant increase in total testosterone levels (from 10.7+/-3.9 nmol/l to 13.4+/-4.7 nmol/l; p<0.001), bioactive testosterone (from 5.21+/-1.87 nmol/l to 6.25+/-2.01 nmol/l; p=0.001), and free testosterone levels (from 0.222+/-0.080 nmol/l to 0.267+/-0.087 nmol/l; p=0.001) were observed in the vitamin D supplemented group. By contrast, there was no significant change in any testosterone measure in the placebo group. Our results suggest that vitamin D supplementation might increase testosterone levels. Further randomized controlled trials are warranted to confirm this hypothesis.


References

Ahmad, M. K., A. A. Mahdi, et al. (2010). "Withania somnifera improves semen quality by regulating reproductive hormone levels and oxidative stress in seminal plasma of infertile males." Fertil Steril 94(3): 989-96.

Pilz, S., S. Frisch, et al. (2010). "Effect of Vitamin D Supplementation on Testosterone Levels in Men." Horm Metab Res.