Dr. Ron’s Research Review – November 19, 2014

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This week’s research review focuses on hypochlorhydria and thyroid.

A study published in Acta medica Scandinavica investigated gastric secretion in 15 consecutive thyroid disease patients, ten with hyperthyroidism and five with hypothyroidism. Gastric secretion of acid and intrinsic factor was studied in the patients both basally and with the augmented histamine test.

In eight patients with hyperthyroidism and all patients with hypothyroidism, the gastric secretion of acid after histamine stimulation was significantly lowered. The secretion of intrinsic factor correlated with the secretion of acid, and was significantly depressed in four patients with hyperthyroidism and three with hypothyroidism. (Dotevall and Walan, 1969)

 

Dr. Ron


 

Articles

Gastric secretion of acid and intrinsic factor in patients with hyper- and hypothyroidism
(Dotevall and Walan, 1969) Download
Fifteen consecutive thyroid disease patients, ten with hyperthyroidism and five with hypothyroidism, have been investigated as far as gastric secretion was concerned. Gastric secretion of acid and intrinsic factor was studied in the patients both basally and with the augmented histamine test. In eight patients with hyperthyroidism and all patients with hypothyroidism, the gastric secretion of acid after histamine stimulation was significantly lowered. The secretion of intrinsic factor correlated with the secretion of acid, and was significantly depressed in four patients with hyperthyroidism and three with hypothyroidism. Further studies showed pernicious anemia in two patients with hypothyroidism.

 

References

Dotevall, G. and A. Walan (1969), ‘Gastric secretion of acid and intrinsic factor in patients with hyper- and hypothyroidism’, Acta Med Scand, 186 (6), 529-33. PubMedID: 5382072