Dr. Ron’s Research Review – January 7, 2015

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This week’s research review focuses on multiple sclerosis and fat malabsorption.

A case report published in Lancet, 1978 describes fat malabsorption in multiple sclerosis. (Fantelli et al., 1978)

In investigating fifty-two patients with M.S. for evidence of malabsorption, a study found low five- hour excretions of Dxylose in 27%, abnormal stool fat and undigested meat fibers in around 40%, and malabsorption of vitamin B12 in 12%. One other patient, not in this series, had villous atrophy. Usually, the mucosa appears normal under light microscopy; in certain patients, increased inflammatory cells are present. (Cook et al., 1978)

Fat absorption was studied in 24 patients with clinically definite multiple sclerosis and in 36 healthy control subjects. Beta-carotene and vitamin A in their plasma were also measured. This double-blind and randomized study showed no differences between these two populations with regard to the three parameters. They did not find evidence for fat malabsorption in multiple sclerosis. (Wong et al., 1993)

Dr. Ron


 

Articles

Multiple sclerosis and malabsorption
            (Cook et al., 1978) Download
In investigating fifty-two patients with M.S. for evidence of malabsorption, a study found low five- hour excretions of Dxylose in 27%, abnormal stool fat and undigested meat fibres in around 40%, and malabsorption of vitamin B12 in 12%. One other patient, not in this series, had villous atrophy. Usually, the mucosa appears normal under light microscopy; in certain patients, increased inflammatory cells are present.

Multiple sclerosis and malabsorption
            (Fantelli et al., 1978) Download

Intestinal absorption of dietary fat in patients with multiple sclerosis.
            (Wong et al., 1993) Download
Fat absorption was studied in 24 patients with clinically definite multiple sclerosis and in 36 healthy control subjects. Beta-carotene and vitamin A in their plasma were also measured. This double-blind and randomized study showed no differences between these two populations with regard to the three parameters. We did not find evidence for fat malabsorption in multiple sclerosis.

 

References

Cook, A. W., et al. (1978), ‘Multiple sclerosis and malabsorption’, Lancet, 1 (8078), 1366. PubMedID: 78135
Fantelli, F. J., H. Mitsumoto, and B. A. Sebek (1978), ‘Multiple sclerosis and malabsorption’, Lancet, 1 (8072), 1039-40. PubMedID: 76951
Wong, EK Jr, et al. (1993), ‘Intestinal absorption of dietary fat in patients with multiple sclerosis.’, Metab Pediatr Syst Ophthalmol, 16 (3-4), 39-42. PubMedID: 8090084