Dr. Ron’s Research Review – September 2, 2015

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This week’s research review focuses on Horsetail mixture on rheumatoid arthritis.

A total of 60 cases of patients with RA were randomly divided into experimental group and control group (5 men and 25 women.) Results showed that the total effective rate of experimental group was 80%, while that of control group was 16.67%.

Both groups were treated with methotrexate (7.5mg, once a week) and diclofenac sodium (25mg, 3x/day). The experimental group added Horsetail mixture (15mL 3x/day). Both treatment courses were for three months.

 

Group

CRP (mg/L)

ESR (mm/h)

RF (mm/h)

 

Before

After

Before

After

Before

After

Horsetail

33±18

13±9

51±30

21±13

316±194

146±122

Control

33±34

17±20

36±35

25±22

197±193

144±181

 

Dr. Ron


 

Articles

Horsetail mixture on rheumatoid arthritis and its regulation on TNF-alpha and IL-10.
            (Jiang et al., 2014) Download
Taking autoimmune inflammation of rheumatoid arthritis as entry point, this paper discussed the clinical effect of horsetail mixture on rheumatoid arthritis (RA) and its mechanism. A total of 60 cases of patients with RA were randomly divided into experimental group and control group using randomized controlled trial. We observed its biochemistry, TNF-alpha and IL-10 before and after treatment, and then systematically assessed the clinical effect of horsetail on RA. Results showed that the total effective rate of experimental group was 80%, while that of control group was 16.67%. After statistical treatment, the differences between two groups were significant (p<0.01). Comparison of the difference value of TNF-alpha (p<0.05) and IL-0.05 in serum between groups before and after treatment, there were significant differences. Comparison of CRP within group before and after treatment was significantly different (p<0.05), while comparison of CRP between groups was not significantly different (p>0.05). Comparison of ESR and RF within group before and after treatment was significantly different (p<0.01), and comparison of them between groups was also significantly different (p<0.05). Comparison of difference values within group before and after treatment were also significantly different (p<0.01). It was concluded that horsetail mixture has remarkable curative effect on rheumatoid arthritis, and its clinical application is safe and reliable. It has obvious down regulatory effect on cell factor TNF-alpha related to RA, that is, it can down regulate the level of pre-inflammatory factor TNF-alpha as well as the level of anti-inflammatory factor IL-10. Therefore, it is considered that the regulating effect of horsetail mixture on TNF-alpha and IL-10 is one of the mechanisms of its treatment on RA.

 

 

References

Jiang, X, et al. (2014), ‘Horsetail mixture on rheumatoid arthritis and its regulation on TNF-alpha and IL-10.’, Pak J Pharm Sci, 27 (6 Suppl), 2019-23. PubMedID: 25410066