Dr. Ron’s Research Review – March 2, 2016

©                                                                                                                 

This week’s research review focuses on primary locus intervention

Primary Locus Intervention targets the progressive, age-related decline in hormone production at the highest neuroendocrine level of organization. Unlike end-product HRT, the objective of PLI therapy is to restore feedback and other normal physiological relationships within the brain-neuroendocrine complex and thereby to restore youthful endogenous hormone production/ secretion. (Walker, 2007)
The intervention is based upon the observation that dopamine receptors decline in the human brain with aging and the idea that age-distortion of catecholamine (norepinephrine and dopamine) and indoleamine (serotonin) neurotransmitter dynamics is a higher order, if not primary neuroendocrine defect. Dopamine and norephinephrine are known to promote release of pituitary hormones including GH and gonadotropins.
During aging, steady state concentrations and turnover of these catecholamines in hypothalamic regions responsible for control of pituitary function are significantly reduced compared to youth while relative concentrations of serotonin increase. Presumably, such imbalance leads to inhibitory serotonin dominance These changes may contribute at least in part to the age-related decline in pituitary hGH and other hormones.

Mucuna pruriens provides catecholamine and acetylcholine precursors.
Lycium chinense, Uncaria rhynchophylla, and Ginkgo biloba contains monoamine oxidase inhibitors.
Dimethylaminoethanol is an acetylcholinesterase inhibitor having the potential to increase brain acetylcholine.
Lepidium meyenii or Maca which directly stimulates production of important pituitary hormones

Dr. Ron


 

Articles

Primary locus intervention: a novel approach to treating age-associated hormone insufficiency.
            (Walker, 2007) Download
Primary Locus Intervention targets the progressive, age-related decline in hormone production at the highest neuroendocrine level of organization. Unlike end-product HRT, the objective of PLI therapy is to restore feedback and other normal physiological relationships within the brain-neuroendocrine complex and thereby to restore youthful endogenous hormone production/ secretion.

 

References

Walker, RF (2007), ‘Primary locus intervention: a novel approach to treating age-associated hormone insufficiency.’, Clin Interv Aging, 2 (4), 495-97. PubMed: 18225449