Dr. Ron’s Research Review – May 25, 2016

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This week’s research review focuses on estrogen and prostate cancer.

The mainstay targets for hormonal prostate cancer (PCa) therapies are based on negating androgen action. Recent epidemiologic and experimental data have pinpointed the key roles of estrogens in PCa development and progression. Racial and geographic differences, as well as age-associated changes, in estrogen synthesis and metabolism contribute significantly to the etiology. This article summarizes how different estrogens, anti-estrogens and estrogen mimics contribute to prostate carcinogenesis, the roles of the different mediators of estrogen in the process, and the potentials of new estrogenic/anti-estrogenic compounds for prevention and treatment of prostate cancer. (Ho et al., 2011)

Estrogens have significant direct and indirect effects on prostate gland development and homeostasis and have been long suspected in playing a role in the etiology of prostatic diseases. Direct effects are mediated through prostatic estrogen receptors alpha (ERalpha) and beta (ERbeta) with expression levels changing over time and with disease progression. This review examines the evidence for a role of estrogens and specific estrogen receptors in prostate growth, differentiation and disease states including prostatitis, benign prostatic hyperplasia (BPH) and cancer and discusses potential therapeutic strategies for growth regulation via these pathways. (Prins and Korach, 2008)

 

Dr. Ron


 

Articles

Estrogens and prostate cancer: etiology, mediators, prevention, and management.
            (Ho et al., 2011)  Download
The mainstay targets for hormonal prostate cancer (PCa) therapies are based on negating androgen action. Recent epidemiologic and experimental data have pinpointed the key roles of estrogens in PCa development and progression. Racial and geographic differences, as well as age-associated changes, in estrogen synthesis and metabolism contribute significantly to the etiology. This article summarizes how different estrogens/antiestrogens/estrogen mimics contribute to prostate carcinogenesis, the roles of the different mediators of estrogen in the process, and the potentials of new estrogenic/antiestrogenic compounds for prevention and treatment of PCa.

The role of estrogens and estrogen receptors in normal prostate growth and disease.
         (Prins and Korach, 2008) Download
Estrogens have significant direct and indirect effects on prostate gland development and homeostasis and have been long suspected in playing a role in the etiology of prostatic diseases. Direct effects are mediated through prostatic estrogen receptors alpha (ERalpha) and beta (ERbeta) with expression levels changing over time and with disease progression. The present review examines the evidence for a role of estrogens and specific estrogen receptors in prostate growth, differentiation and disease states including prostatitis, benign prostatic hyperplasia (BPH) and cancer and discusses potential therapeutic strategies for growth regulation via these pathways.

 

References

Ho, SM, et al. (2011), ‘Estrogens and prostate cancer: etiology, mediators, prevention, and management.’, Endocrinol Metab Clin North Am, 40 (3), 591-614, ix. PubMed: 21889723
Prins, GS and KS Korach (2008), ‘The role of estrogens and estrogen receptors in normal prostate growth and disease.’, Steroids, 73 (3), 233-44. PubMed: 18093629