Dr. Ron’s Research Review – October 30, 2019

©

This week’s research review focuses on the urinary iodine loading test.

Optimox, the suppliers of Ioderal, a tablet form of Lugol solution (iodide/iodine), has an extensive collection of research articles.
https://www.optimox.com/iodine-research
https://www.optimox.com/shop/iodoral/

To test whole body sufficiency for iodine, 4 tablets of Iodoral® are ingested, followed by 24 hr. urine collection. The more deficient a subject is in iodine, the more iodine is retained by the body and the least excreted in the urine. Sufficiency is achieved when 90% or more of the ingested amount is excreted in the urine. In most subjects tested, 3-4 tablets of Iodoral®/day were required to achieve whole body sufficiency within 3 months and the body retained approximately 1.5 gm iodine at sufficiency.
Whole body sufficiency for iodine correlates well with overall wellbeing, and some subjects could tell when they achieved sufficiency even before knowing the results of the test. Iodine sufficiency was associated with a sense of overall wellbeing, lifting of a brain fog, feeling warmer in cold environments, increased energy, needing less sleep, achieving more in less time, experiencing regular bowel movements and improved skin complexion.
The nutrient iodine is essential for every cell of the human body requiring peripheral concentrations of inorganic iodide ranging from 10-6M to 10-5M. In non-obese subjects, these concentrations can be achieved with daily intake of 12.5-50 mg elemental iodine. The iodine/iodide loading test and serum inorganic iodide levels are reliable means of assessing whole body sufficiency for elemental iodine and also for quantifying the bioavailability of the forms of iodine ingested.
Of all the elements known so far to be essential for health, iodine is the most misunderstood and the most feared. Yet, it is by far the safest of all the trace elements known to be essential for human health. It is the only trace element that can be ingested safely in amounts up to 100,000 times the RDA. To test whole body sufficiency for iodine, 4 tablets of Iodoral® are ingested, followed by 24 hr. urine collection. The more deficient a subject is in iodine, the more iodine is retained by the body and the least excreted in the urine. Sufficiency is achieved when 90% or more of the ingested amount is excreted in the urine. In most subjects tested, 3-4 tablets of Iodoral®/day were required to achieve whole body sufficiency within 3 months and the body retained approximately 1.5 gm iodine at sufficiency.

Guy E. Abraham, MD, is a former Professor of obstetrics, Gynecology and Endocrinology at the UCLA School of Medicine. Some 35 years ago, he pioneered the development of assays to measure minute quantities of steroid hormones in biological fluids. He has been honored as follows: General Diagnostic Award from the Canadian Association of Clinical Chemists, 1974; the “Medaille d’Honneur” from the University of Liege, Belgium, 1976; the Senior Investigator Award of Pharmacia, Sweden, 1980. The applications of Dr. Abra- ham’s techniques to a variety of female disorders have brought a notable improvement to the understanding and management of these disorders. Twenty-five years ago, Dr. Abraham developed nutritional programs for women with premenstrual tension syndrome and post menopausal osteoporosis. They are now the most commonly used dietary programs by American obstetricians and gynecologists. Dr . Abraham’ s current research in- terests include the development of assays for the measurement of iodide and the other halides in biological fluids and their applications to the implementation of orthoiodosupplementation in medical practice.

Dr. Ron

 


Articles

 

The Iodine-Iodide Loading Test
            (Abraham, 2016) Download

The concept of orthoiodosupplementation and its clinical implications.
            (Abraham, 2004b) Download

The safe and effective implementation of orthoiodosupplementation in medical practice.
            (Abraham, 2004a) Download

The bioavailability of iodine applied to the skin
            (Abraham, 2008) Download

 

References

Abraham, GE (2004a), ‘The safe and effective implementation of orthoiodosupplementation in medical practice.’, Internist, 11 17-36. PubMed:
——— (2004b), ‘The concept of orthoiodosupplementation and its clinical implications.’, Internist, 11)2) 29-38. PubMed:
——— (2008), ‘The bioavailability of iodine applied to the skin’, Internist, 15 (2), 77-79. PubMed:
———. (2016). The Iodine-Iodide Loading Test. Retrieved from http://www.optimox.com/iodine-study-21